Homology model allows effective virtual screening

A Homology Based Model and Virtual Screening of Inhibitors for Human Geranylgeranyl Transferase 1 (GGTase1)

Protein prenylation is a post translational modification that is indispensable for Ras-Rho mediated tumorigenesis. In mammals, three enzymes namely protein farnesyltransferase (FTase), geranylgeranyl transferase1 (GGTase1), and geranylgeranyl transferase2 (GGTase2) were found to be involved in this process. Usually proteins of Ras family will be farnesylated by FTase, Rho family will be geranyl...

Effective homology, a survey.∗

Algebraic topology consists in associating to topological spaces algebraic invariants in order to describe their essential properties. In some (exceptional) cases, it is possible in this way to classify a particular topological space inside a more or less large set of spaces or equivalence classes of spaces, for example up to homotopy equivalence. In the most important cases, a functor is defin...

A model to develop effective virtual teams

School of Management, Edith Cowan University, Australia [email protected] Dr Ying-Chieh Liu Department of Information Management, Chaoyang University of Technology, Taiwan [email protected] A review of the literature shows the factors that impact on the effectiveness of virtual teams are still ambiguous. To address this problem we developed a research design that included a meta-analysis...

Discovery of Novel Inhibitors for Nek6 Protein through Homology Model Assisted Structure Based Virtual Screening and Molecular Docking Approaches

Nek6 is a member of the NIMA (never in mitosis, gene A)-related serine/threonine kinase family that plays an important role in the initiation of mitotic cell cycle progression. This work is an attempt to emphasize the structural and functional relationship of Nek6 protein based on homology modeling and binding pocket analysis. The three-dimensional structure of Nek6 was constructed by molecular...

Effective Homology and Spectral Sequences